Right ventricular mechanics among beta-thalassemia major patients

Abstract Introduction Right ventricular function among β-thalassemia (β-TM) patients is affected by both pulmonary circulation pressure and primary iron deposition on right myocardium. Purpose In our study we aimed to detect the presence of impaired ventricle (RV-PC) coupling applying novel echocardiographic techniques these patients. Methods 47 β-TM (mean age 39.02±8.76 years, 48.9% male sex) 24, sex matched, healthy controls were examined transthoracic echocardiography. Conventional parameters estimated (LVEF, E/e' ratio, left atrial volume index (LAVI), systolic (RVSP), S' wave tricuspid annulus), alongside with deformation indices (left strain at reservoir phase (LASr), free wall (RVfw) 4 chamber (RV4c) strain), as well RV-PC expressed S'/RVSP, RVfw/RVSP RV4c/RVSP. T2* was calculated cardiac magnetic resonance imaging in patient group. Results LVEF, LAVI, RVSP, LASr, RVfw, RV4c, RV4c/RVSP differed significantly between (Table 1). did not correlate either or indices. A correlation found regarding LASr S'/RVSP (r=0.383, p=0.008) (r=−0.388, p=0.007) but RVfw/PVSP 2). Conclusions be compared controls, they do seem associated myocardial load (T2* index). also a strain. The latter suggests that cardiomyopathy could coupling. Funding Acknowledgement Type funding sources: None.